Chemistry and Biochemistry

Gilead Innovation Initiative opens doors for SFSU student scientists

The new initiative provides stipends, lab support and opportunities for first-time and emerging researchers

Elmer Guzman didn’t always see himself as a researcher. A first-generation Chemistry senior at San Francisco State University, he wasn’t sure he belonged in a lab until this summer, when he became one of the first Gilead Innovation Initiative Scholars.

“It makes me feel proud of myself,” Guzman said. “Just seeing the recognition and knowing that there are opportunities trying to help students who are new to research makes me feel like there is a future to these things.”

Guzman is one of 30 student scientists who made up the first cohort of the Gilead Innovation Initiative at SFSU. The Gilead Foundation generously gifted $1.25 million in programmatic support to SFSU’s College of Science & Engineering (CoSE) via two awards during fundraising for the University’s new Science and Engineering Innovation Center (SEIC). In addition to supporting student research activities, the foundation also provided $3.75 million to outfit SEIC labs with state-of-the-art equipment and furnishings.

The Gilead Innovation Scholars — 11 undergraduate and 19 graduate students — were awarded $5,000 stipends to conduct research between June 1 and August 23. (Faculty members were also awarded a $1,000 honorarium for mentoring the scholars). Many of the student awardees were first-time researchers as well as students who had never received financial support for working in research labs. 

The Gilead award is unique in that it is inclusive of research activities throughout CoSE. It included at least one student from each of the eight CoSE departments and schools, supporting the training of astronomers, biologists, chemists, computer scientists, engineers, geologists, mathematicians, physicists, psychologists and others. Projects ranged from molecular biology and ecology to nanoparticles, artificial intelligence, youth psychology and many other topics in science and engineering. 

Elmer working in chemical hood
Lilly holding and looking at a small bird
Gabriel adjusting a microscope

‘I’m moving in the right direction’

Guzman spent the summer in Associate Professor Jingjing Qiu’s lab, exploring chemistry and renewable energy. He is testing the stability of gold and nickel in electrodes for the electrochemical oxidation of benzyl alcohol. His work could one day help make industrial chemical processes more sustainable. But for him, the more immediate outcome was confidence. 

“I definitely see myself going down this route, trying to pursue higher education and keep doing research,” he said. He’s already presented his work on campus and is excited to continue this work and possibly attend an external scientific conference later this year.

As Guzman pushed the boundaries of renewable energy in the lab, Lilly Raphaelian was outdoors gathering clues about a new avian virus that could impact local bird ecology. As a second-year Cellular and Molecular Biology master’s student working with Biology Professor Ravinder Sehgal, she studies Russian Doll Virus (aka Matryoshka virus), a virus that infects a parasite that infect birds — hence the Russian doll moniker. The parasite is the number-one killer of birds and is widespread in warmer climates. 

Beyond wanting to understand how the virus is impacting the parasite, she is also optimizing an imaging technique (RNAscope) to detect the virus in blood smears. The technique is typically done with tissue samples, but her approach is safer for birds. 

There are a lot of unknowns and challenges, Raphaelian explains, but the experience has been rewarding. She considers this her first proper research experience — “[The Gilead award] is my first grant ever!” she added excitedly — and in just one year she’s written proposals and grants, learned research skills, created posters, given scientific presentations, taught students in and out of the classroom and collaborated with local and international scientists. 

Lilly teaching another student how to collect and prep samples

“It feels like I’m moving in the right direction,” Raphaelian said, noting she wants to become a professor. “I hope to achieve many more grants in my lifetime. It’s making me feel like I’m capable and I’m supposed to be here.”

‘There’s an astrophysicist that looks like me!’

 A Ph.D.-bound grad student like Raphaelian, Gabriel Munoz Zarazua was always fascinated by the mysteries of the universe. But he didn’t always think he could be an astrophysicist. Thanks to his own perseverance and support from mentors (and the Gilead Foundation), he’s now an SFSU astrophysicist collaborating with researchers all over the nation. 

Working with Physics and Astronomy Assistant Professor Eileen Gonzales, Munoz Zarazua is studying the formation of Ross 458 c, a brown dwarf planet that orbits a binary star system. Although they form like stars, brown dwarfs lack the mass to radiate starlight so they fall somewhere between a star and a giant planet. 

To better understand Ross 458 c, Munoz Zarazua is using data from the James Web Space Telescope (JWST) to examine the object’s atmosphere. It could offer new insights into how this brown dwarf formed and help define and compare brown dwarfs, planets and stars.

Munoz Zarazua is also part of a larger scientific collaboration with scientists from all over the country. He meets with the group every few weeks and has interacted with collaborators at scientific conferences. The experience has been invaluable because these collaborators may become future colleagues or mentors during his Ph.D. or later in his career.

Despite his passion for astronomy research, Munoz Zarazua was hesitant to commit to this path. Earlier in his career, he didn’t think he had the necessary math skills and was discouraged by the lack of scientists who looked like him. 

Gabriel Munoz Zarazua and Professor Eileen Gonzalez

“Now I’m starting to see more. I just got back from a conference in Washington, D.C., and we talked about that,” he explained. “It was so amazing to meet other people that look like me. I want to be that for other students, for the next generation. For them to look up and think, ‘There’s an astrophysicist that looks like me. If they can do it, I can do it too.’” 

Learn more about SFSU’s College of Science & Engineering.

SFSU celebrates new Science and Engineering Innovation Center with dedication ceremony

The new science building creates a dynamic, inclusive learning environment by ‘putting science on display’

SAN FRANCISCO January 24, 2025 – San Francisco State University (SFSU) held a dedication ceremony today for its new Science and Engineering Innovation Center (SEIC), an all-electric science building filled with innovative student-centric teaching spaces. Located prominently on 19th Avenue, the building was constructed with the future in mind, specifically designed to prepare students for various STEM workforces while emphasizing student academic support and sustainability.  

“In some ways more important from the local perspective, 80% of our science and engineering alumni live in the Bay Area, 83% stay in California and 8% of the employees in the largest Bay Area biopharma companies are [from] San Francisco State. This new center will grow the already significant number of alumni working in the Bay Area STEM industries by preparing our graduates to better compete in these fields. An investment in San Francisco State is an investment in the health and future of California,” said San Francisco State University President Lynn Mahoney during the ceremony.

At the ceremony, San Francisco Board of Supervisors President Rafael Mandelman, District 19 Assemblymember Catherine Stefani and CEO of Gilead Daniel O’Day shared SF State’s role in the biotech and engineering pipelines and how SEIC will prepare SFSU’s diverse students for the industry workforce. 

The ceremony marked the completion of the new 125,000-square-foot SEIC building and renovation of the existing adjacent Science Building. SEIC is home to the College of Science & Engineering’s (CoSE) Department of Chemistry & Biochemistry and School of Engineering (SOE), as well as the CoSE dean’s office and the College of Professional & Global Education (CPaGE) campus operations on the fifth floor.  

The college anticipates SEIC will serve all 7,000 CoSE students and thousands of general education students each year. The building is also open to the University community for seminars, workshops, student activities and more. CoSE Dean Carmen Domingo hopes that the building will be an inclusive space where students can see themselves as future engineers, chemists and scientists. By “putting science on display,” SEIC can help demystify what it means to be a scientist — and who can be in these fields.  

“The SEIC is more than a science building; it’s an inclusive space for students to explore, innovate and learn with cutting-edge technology and talented faculty,” said Domingo. “This major achievement, made possible by our generous partners and donors, will help thousands of diverse graduates make a profound impact on our regional workforce.”

A few of SEIC’s highlights include: 

  • A configurable large learning space for over 100 students on the first floor that can be rearranged to facilitate group work, with an interactive AV system that allows students and instructors to dynamically share work and learn from each other. 
  • Three studio-style integrated lecture/lab chemistry classrooms  
  • Chemistry research labs with industry-standard equipment, introducing new experimental capabilities for protein crystallography, enzyme kinetics and drug development 
  • A robotics and mechatronics lab with a multi-robotic-arm-automatized assembly line 
  • Power systems (a collaboration with PG&E) and energy systems labs (supporting a Department of Energy-funded Center of Excellence in energy efficiency) to study power distribution and HVAC/energy research, respectively 
  • A structural and seismic engineering lab with strong wall and floor and a robotic motion platform to test structural dynamics, hazard mitigation and more 
  • A makerspace and two garages with large and small machining equipment for student projects, like concrete canoes, Formula 1 SAE racecars, steel bridges and other senior projects 
Three engineering students looking up at a robotic arm
Two chemists working in the lab
Two chemists working in a lab

New equipment and programs in the building were funded by the Catalyze the Future campaign, which raised over $25 million from private sources. Individual donors — alumni and non-alumni alike — made generous gifts to support SFSU’s continued leadership in fueling the region’s biotech and tech workforce pipelines. Industry partners such as the Genentech Foundation, Gilead Foundation, Agilent and Keysight were among the generous corporate donors helping outfit SEIC with the cutting-edge research equipment and support for student success initiatives and programming. Additionally, a $5 million challenge grant from the Wayne and Gladys Valley Foundation was crucial to the campaign’s success. 

Based on student feedback, SEIC includes comfortable study spaces with ample natural light throughout the building. The design also incorporated spacious workspaces for group work, such as tutoring and senior projects. Many of the rooms and labs have large windows so visitors can see research happening in real time.  

“It’s really cool. We have a building we can be proud of and say, ‘Come, check out this work,’” said Senior Computer Engineer Emely Villa, who has been looking forward to working in SEIC since coming to SFSU in 2021. “There are a lot of display areas, too, where our old projects are going to be able to be displayed. … It’s very nice to be proud of showcasing the work at the new [SEIC].” 

SEIC is on track for LEED (Leadership in Energy & Environmental Design) Gold certification. In November, at the CSU Facilities Management conference, SEIC won two awards for the architecture and engineering and the energy efficiency categories. The building is SFSU’s first all-electric building with a micro-grid; it has roof-top solar panels and a battery back-up power system. The landscaping incorporated adaptive and native plants, no-mow grass and bioswale to improve its resistance to climate change.   

Learn more about SFSU’s College of Science & Engineering.  

SFSU receives cutting-edge Agilent technology for new Science and Engineering Innovation Center

The gift provides world-class instrumentation to foster the next generation of STEM innovators 

SAN FRANCISCO – January 21, 2025 – San Francisco State University (SFSU) has announced that Agilent Technologies, a global leader in analytical and clinical laboratory technologies, has donated $1.7 million worth of analytical instrumentation for its new Science and Engineering Innovation Center (SEIC).

“Agilent’s generosity is not only an investment in our students and their success but also the greater workforce. By providing state-of-the-art equipment, students now have access to the next generation of tools for scientific discovery in the fields of chemistry, materials science, biochemistry and the life sciences,” said SFSU Dean of the College of Science & Engineering Carmen Domingo. “Agilent’s new equipment allows students to greatly expand and sharpen their skills ensuring that they are well-prepared to enter the workforce or pursue higher degrees with confidence. We are grateful for Agilent’s support in this endeavor.” 

The donation will equip SEIC chemistry and biochemistry labs with Agilent technologies, enabling students to learn with world-class instrumentation and excel in our global society. In recognition of the donation, SEIC suite 201 has been named the ‘Agilent Technologies Teaching Laboratory.’ The suite is equipped with the highest number of Agilent instruments in the SEIC and is primarily used for upper-division chemistry and biochemistry courses. 

The new equipment is already making a tremendous impact on students like Marcello Garbo, a senior majoring in Chemistry. Garbo says before the donation, there was a limited amount of equipment that had to be shared among students and faculty. The equipment was also spread across different rooms. With more equipment that is placed in a centralized area, it speeds up the process for various tasks. 

“Every five to 10 minutes, I’d have four samples that I’d have to run at the same time. And then I’d also have to go all the way down the hall in order to run them,” Garbo said while describing his experience before the new Agilent equipment. 

Garbo also says the technology has been able to capture higher quality data, which has led to better scientific conclusions and more presentable information. 

"Agilent is committed to fostering innovation and excellence in STEM education, and our donation to SFSU is an example of that,” said Padraig McDonnell, Agilent president and CEO.  “By equipping the chemistry and biochemistry labs, we aim to empower students from all backgrounds to excel in their studies and future careers.” 

The new equipment will also strengthen the way faculty teach and conduct research. 

“This technology will significantly enhance faculty’s ability to deliver hands-on, real-world learning experiences that’ll prepare our students for fulfilling careers in STEM,” said Bruce Manning, SFSU Chair of the Department of Chemistry and Biochemistry. “It will also open new doors for faculty research, enabling us to pursue more advanced projects and collaborations.”  
The College of Science & Engineering has steadily grown, and this new 125,000-square-foot science building will help sustain this expansion and support the University’s role as a leader in fueling the workforce of the Bay Area. It will be prominently visible on 19th Avenue and is anticipated to benefit more than 7,000 CoSE students annually. 

Learn more about the Science and Engineering Innovation Center. 

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About San Francisco State University  

San Francisco State University is a public university serving students from the San Francisco Bay Area, across California and around the world, with nationally acclaimed programs that span a broad range of disciplines. More than 22,000 students enroll at the University each year, and its approximately 294,000 graduates have contributed to the economic, cultural and civic fabric of San Francisco and beyond. Through them — and more than 1,800 world-class faculty members — SF State proudly embraces its legacy of academic excellence, community engagement and commitment to social justice. For more information, visit sfsu.edu
 
About Agilent Technologies  
Agilent Technologies Inc. (NYSE: A) is a global leader in analytical and clinical laboratory technologies, delivering insights and innovation that help our customers bring great science to life. Agilent’s full range of solutions includes instruments, software, services, and expertise that provide trusted answers to our customers' most challenging questions. The company generated revenue of $6.51 billion in fiscal year 2024 and employs approximately 18,000 people worldwide. Information about Agilent is available at www.agilent.com. 

Alumnus thanks SF State mentors for his success as research faculty

Alum Juan Mendoza (B.S., ’03) says SF State gave him the foundation to be one of the top researchers in the United States

San Francisco State University alumnus Juan Mendoza gets emotional thinking about how much has changed in his family in just one generation. His parents immigrated to the United States from a small farming town in Mexico where they had limited educational opportunities. Thanks to them, Mendoza is now at a top research university as a faculty scientist whose accomplishments were recently recognized by one of the premier research organizations in the United States.

“That potential is out there. It could be anyone. [But] I had to be found to be where I am,” said Mendoza (B.S., ’03), crediting San Francisco State’s part in his journey. When the Howard Hughes Medical Institute (HHMI) named him one of 31 inaugural Freeman Hrabowski scholars earlier this year, he was quick to thank his SF State mentors for setting him up for success. Mendoza’s recent accolade recognizes early career faculty for their outstanding research and commitment to diversity, equity and inclusion in science. The research award provides up to $8.6 million for each scholar for the next 10 years.

“Working at San Francisco State with other students is when I fell in love with research science. That got me through the really tough times at the graduate level and at the postdoc level and still gets me through hard times now as faculty as well,” said Mendoza, who is an assistant professor at the University of Chicago’s Pritzker School of Molecular Engineering.

As an undergrad, Mendoza originally transferred to SF State from a private university in Washington state because it was more affordable. An aspiring physician, he was a Biochemistry major but struggled academically, partly because he worked so much. He ultimately left school early to join the dot-com boom and worked in tech for a few years. When the economic upheaval after 9/11 left him unemployed, Mendoza returned to SF State to finish his bachelor’s degree.

“I don’t know how but somehow [Frank Bayliss] found me,” Mendoza said, explaining that Bayliss — the director of the Student Enrichment Opportunities (SEO) office at the time — completely shifted his educational experience. Bayliss helped Mendoza get a fellowship and connect with SF State faculty.

“What really changed my life was being able to focus on studying and research. That really brought out that excellence in me,” Mendoza said. In addition to financial support, SEO helped him connect with faculty like Chemistry and Biochemistry Professor Raymond Esquerra. This network helped him get research experience and solid letters of recommendation, giving him a chance at really good Ph.D. programs, Mendoza adds.

“Dr. Esquerra is someone that I just completely admire,” said Mendoza, who was a postbaccalaureate researcher in Esquerra’s lab. This lab was where Mendoza fell in love with protein structure and its role in human health and biology. His mentor was the first to encourage Mendoza to combine his computational tech background with chemistry.

“It got me so excited. It gave me that first idea of combining both lab science and computation, which at that time was a lot rarer than it is now,” he explained. Computational science is now heavily integrated into many life science and biotech jobs.

At the University of Chicago, Mendoza runs his own lab and mentors his own host of students. His group studies the biophysics of the immune system. They want to understand how proteins interact and how scientists can bioengineer protein structure and protein interactions to improve human health. His lab also uses computational tools to advance protein engineering. So much of this started at SF State, says Mendoza — and he’s determined to give his students the same kind of support that made such a difference for him.

“I want to pay it back,” he said. “I’m just one person, but San Francisco State and the SEO office have helped so many people. I’m just trying to do my little part, not only in my lab, but in other parts of campus.”

Learn more about SF State’s Department of Chemistry and Biochemistry and Student Enrichment Opportunities (SEO) office.